Evidence for active transport of the dipeptide glycylsarcosine by hamster jejunum in vitro.

Kinetics of mucosal influx of glycylsarcosine, glycine and leucine into hamster jejunum and ileum in vitro.

1. This paper describes an investigation of the kinetics of influx of the dipeptide glycylsarcosine and the amino acids glycine and L-leucine into rings of everted hamster small intestine in vitro, in proximal and distal small intestine (jejunum and ileum). Results were expressed per unit wet weight of intestine. 2. At all concentrations studied (0.1--100 mmol/l), influx of glycylsarcosine was ...

Influx of two dipeptides, glycylsarcosine and L-glutamyl-L-glutamic acid, into hamster jejunum in vitro.

1. This paper reports an investigation of whether the dipeptides glycylsarcosine and L-glutamyl-Lglutamic acid share a single mediated transport mechanism into hamster jejunum, or whether one of these peptides is transported in part by a transport mechanism unavailable to the other. It describes the kinetics of influx of glycylsarcosine and of L-glutamyl-L-glutamic acid into rings of everted ha...

Influx of glycylsarcosine and L-lysyl-L-lysine into hamster jejunum in vitro.

1. This paper reports an investigation of whether the dipeptides glycylsarcosine and L-lysyl-L-lysine share 'a single mediated transport mechanism into hamster jejunum, or whether one of these peptides is taken up in part by a mediated mechanism unavailable to the other. The investigation, using rings of everted jejunum in vitro, was carried out at pH 5 in order to reduce brush border and/or in...

Uptake of L-valyl-L-valine and glycylsarcosine by hamster jejunum in vitro.

Distribution and properties of the glycylsarcosine-transport system in rabbit renal proximal tubule. Studies with isolated brush-border-membrane vesicles.

The distribution and properties of the peptide-transport system in rabbit renal proximal tubule was examined with glycylsarcosine as the substrate and using brush-border-membrane vesicles derived from pars convoluta (outer cortex) and pars recta (outer medulla). The dipeptide was transported into these vesicles against a concentration gradient in the presence of an inward-directed H+ gradient, ...